RAISED PLASMA ENDOTHELIN DURING ACUTE MIGRAINE ATTACK

被引：52

作者：

FARKKILA, M ^{[1
]}

PALO, J ^{[1
]}

SAIJONMAA, O ^{[1
]}

FYHRQUIST, F ^{[1
]}

机构：

[1] UNIV HELSINKI, DEPT MED 4, SF-00290 HELSINKI 29, FINLAND

来源：

CEPHALALGIA | 1992年 / 12卷 / 06期

关键词：

Endothelin; migraine; vasoconstriction;

D O I：

10.1111/j.1468-2982.1992.00383.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Endothelins are the most potent vasoconstrictor peptides known. Plasma endothelin (ET-1) concentrations were measured in eight migraine patients (mean age 44.5 years), two during an acute migraine attack with aura and six during an attack without aura. The mean ET-1 values were elevated in all migraine patients above the range of normal subjects, and were 10.6 (range 6.0-16.0) pg/ml in migraine patients and 3.8 (range 0.7-5.8) pg/ml in controls. We hypothesize that ET-1 may constrict cerebral vessels during the initial stage of the migraine attack.

引用

页码：383 / 384

页数：2

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