RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA PROMOTES ADHERENCE OF STAPHYLOCOCCUS-AUREUS TO CULTURED HUMAN ENDOTHELIAL-CELLS

被引：26

作者：

CHEUNG, AL ^{[1
]}

KOOMEY, JM ^{[1
]}

LEE, SN ^{[1
]}

JAFFE, EA ^{[1
]}

FISCHETTI, VA ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,DEPT MED,DIV HEMATOL ONCOL,NEW YORK,NY 10021

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 10期

关键词：

D O I：

10.1128/IAI.59.10.3827-3831.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF), a potent inflammatory mediator secreted by monocytes during inflammation, was shown to significantly increase the adherence of Staphylococcus aureus to cultured human umbilical vein endothelial cells in vitro. The stimulatory effect of TNF was dose dependent and was bimodal with respect to time; bacterial adhesion peaked after 4 and 16 h of stimulation with recombinant human TNF-alpha. The ability of TNF-alpha to augment staphylococcal adherence to endothelial cells was contingent upon the presence of plasma factors. Thus, the complex interaction among cytokines (such as TNF), plasma factor(s), and the endothelium serves to modulate bacterial adherence to endothelial cells.

引用

页码：3827 / 3831

页数：5

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