TRANSCRIPTIONAL ACTIVATION BY NUR77, A GROWTH FACTOR-INDUCIBLE MEMBER OF THE STEROID-HORMONE RECEPTOR SUPERFAMILY

被引：62

作者：

DAVIS, IJ ^{[1
]}

HAZEL, TG ^{[1
]}

LAU, LF ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL MED,DEPT GENET,808 S WOOD ST,CHICAGO,IL 60612

来源：

MOLECULAR ENDOCRINOLOGY | 1991年 / 5卷 / 06期

关键词：

D O I：

10.1210/mend-5-6-854

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nur77 is a growth factor-inducible immediate early gene that encodes a protein with extensive sequence homology to members of the steroid/thyroid hormone receptor superfamily. By analogy to steroid receptors, the Nur77 protein is thought to act as a ligand-dependent transcription factor that regulates the genomic response to growth factors. Using chimeric gene constructs, we show that Nur77 can indeed function as a transcription activator. Furthermore, Nur77 chimeras can activate transcription in the absence of an exogenously added ligand.

引用

页码：854 / 859

页数：6

共 34 条

[1] CLONING AND EXPRESSION OF THE MOUSE PGK-1 GENE AND THE NUCLEOTIDE-SEQUENCE OF ITS PROMOTER [J].

ADRA, CN ;

BOER, PH ;

MCBURNEY, MW .

GENE, 1987, 60 (01) :65-74

[2] COMPLEXITY OF THE EARLY GENETIC RESPONSE TO GROWTH-FACTORS IN MOUSE FIBROBLASTS [J].

ALMENDRAL, JM ;

SOMMER, D ;

MACDONALDBRAVO, H ;

BURCKHARDT, J ;

PERERA, J ;

BRAVO, R .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) :2140-2148

[3]

AUSUBEL FM, 1990, CURRENT PROTOCOLS MO

[4] GROWTH-FACTORS AND MEMBRANE DEPOLARIZATION ACTIVATE DISTINCT PROGRAMS OF EARLY RESPONSE GENE-EXPRESSION - DISSOCIATION OF FOS AND JUN INDUCTION [J].

BARTEL, DP ;

SHENG, M ;

LAU, LF ;

GREENBERG, ME .

GENES & DEVELOPMENT, 1989, 3 (03) :304-313

[5] GENE-REGULATION BY STEROID-HORMONES [J].

BEATO, M .

CELL, 1989, 56 (03) :335-344

[6]

BRAVO R, 1989, GROWTH FACTORS DIFFE, P324

[7] CHIMERAS OF MYC ONCOPROTEIN AND STEROID-RECEPTORS CAUSE HORMONE-DEPENDENT TRANSFORMATION OF CELLS [J].

EILERS, M ;

PICARD, D ;

YAMAMOTO, KR ;

BISHOP, JM .

NATURE, 1989, 340 (6228) :66-68

[8] THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY [J].

EVANS, RM .

SCIENCE, 1988, 240 (4854) :889-895

[9] THE NGFI-B PROTEIN, AN INDUCIBLE MEMBER OF THE THYROID STEROID-RECEPTOR FAMILY, IS RAPIDLY MODIFIED POSTTRANSLATIONALLY [J].

FAHRNER, TJ ;

CARROLL, SL ;

MILBRANDT, J .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (12) :6454-6459

[10] CHARACTERIZATION AND COLOCALIZATION OF STEROID BINDING AND DIMERIZATION ACTIVITIES IN THE MOUSE ESTROGEN-RECEPTOR [J].

FAWELL, SE ;

LEES, JA ;

WHITE, R ;

PARKER, MG .

CELL, 1990, 60 (06) :953-962

← 1 2 3 4 →