CATECHOLAMINE TURNOVER CHANGES IN HYPOTHALAMUS AND DORSAL MIDLINE AREA OF THE CAUDAL MEDULLA-OBLONGATA OF SPONTANEOUSLY HYPERTENSIVE RATS

The central noradrenaline (NA) and adrenaline (A) turnover in 15-16-week-old stroke prone, spontaneously hypertensive (sp-SH) female rats in an advanced stage of hypertension was found to differ from that of normotensive Wistar-Kyoto (WKy) control rats. The catecholamine (CA) levels were measured after inhibition of dopamine-β-hydroxylase (DBH) or of phenylethanolamine-N-methyltransferase (PNMT). In the hypertensive rats the dopamine (DA) and NA levels and the NA turnover were reduced in the hypothalamus, while in the dorsal part of the caudal medulla oblongata NA levels and A turnover were reduced. Changes in hypothalamic DA and NA mechanisms and in A mechanisms in medulla oblongata may therefore be of importance in the blood pressure regulation of sp-SH rats. © 1979.