THE CONTROL OF INTERFERON-INDUCIBLE GENE-EXPRESSION

被引：66

作者：

KERR, IM

STARK, GR

机构：

来源：

FEBS LETTERS | 1991年 / 285卷 / 02期

关键词：

GENE EXPRESSION; INTERFERON-INDUCIBLE; MUTANT; VIRAL INHIBITION;

D O I：

10.1016/0014-5793(91)80802-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-beta-interferons (IFNs) transiently induce genes through the IFN-stimulable DNA response element (ISRE). IFN-cell surface receptor interaction triggers the cytoplasmic activation of the complex primary transcription factor E, which on translocation and interaction with the ISRE initiates transcription. Whether E is activated directly through the receptor(s) or through a more classical second message pathway(s) and the roles of additional factors in the alpha-beta and gamma-IFN responses remain to be established. Meanwhile analysis of mutants has revealed complexity and overlap in the alpha-beta and gamma-IFN response pathways and the products of at least two viruses have been shown to inhibit IFN-inducible gene expression.

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页码：194 / 198

页数：5

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