SEARCHING PROTEIN-STRUCTURE DATABASES HAS COME OF AGE

被引：218

作者：

HOLM, L

SANDER, C

机构：

[1] Protein Design Group, European Molecular Biology Laboratory, Heidelberg

来源：

PROTEINS-STRUCTURE FUNCTION AND GENETICS | 1994年 / 19卷 / 03期

关键词：

ALGORITHMS; STRUCTURE ALIGNMENT; PROTEIN DATA BANK; PROTEIN SUPERFAMILIES; STRUCTURAL HOMOLOGY;

D O I：

10.1002/prot.340190302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of protein structures known in atomic detail has increased from one in 1960 (Kendrew, J.C., Strandberg, B.E., Hart, R.G., Davies, D.R., Phillips, D.C., Shore, V.C. Nature (London) 185:422-427, 1960) to more than 1000 in 1994. The rate at which new structures are being published exceeds one a day as a result of recent advances in protein engineering, crystallography, and spectroscopy. More and more frequently, a newly determined structure is similar in fold to a known one, even when no sequence similarity is detectable. A new generation of computer algorithms has now been developed that allows routine comparison of a protein structure with the database of all known structures. Such structure database searches are already used daily and they are beginning to rival sequence database searches as a tool for discovering biologically interesting relationships. (C) 1994 Wiley-Liss, Inc.

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页码：165 / 173

页数：9

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