High rate of MDR-1 and heterogeneous pattern of MRP expression without gene amplification in endometrial cancer

被引：21

作者：

Esteller, M

MartinezPalones, JM

Garcia, A

Xercavins, J

Reventos, J

机构：

[1] UNIV BARCELONA,HOSP MATERNOINFANTIL VALL HEBRON,REC BIOMED UNIT,E-08035 BARCELONA,SPAIN

[2] UNIV BARCELONA,HOSP MATERNOINFANTIL VALL DHEBRON,DEPT OBSTET & GYNECOL,BARCELONA,SPAIN

[3] UNIV BARCELONA,HOSP MATERNOINFANTIL VALL DHEBRON,DEPT PATHOL,BARCELONA,SPAIN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 63卷 / 06期

关键词：

D O I：

10.1002/ijc.2910630609

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study was undertaken to determine the pattern of expression of 2 molecular markers of multidrug resistance, the MDR-I and MRP genes, in endometrial carcinomas from 50 untreated patients using a PCR semi-quantitative assay. In addition, PCR analysis of MDR-I and MRP gene amplification was obtained in each case. High rate of MDR-I expression without gene amplification was detected in all endometrial-carcinoma samples, as well as in 10 adenomatous hyperplasias and 50 samples of normal endometrium. On the other hand, MRP appeared to be expressed at moderate levels in normal endometrial tissue, while relatively high levels of MRP expression without gene amplification were occasionally observed in endometrial-carcinoma samples. (C) 1995 Wiley-Liss, Inc.

引用

页码：798 / 803

页数：6

共 23 条

[1] THE GENE ENCODING MULTIDRUG RESISTANCE IS INDUCED AND EXPRESSED AT HIGH-LEVELS DURING PREGNANCY IN THE SECRETORY EPITHELIUM OF THE UTERUS [J].