ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASES BY VASCULAR ENDOTHELIAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR IN CAPILLARY ENDOTHELIAL-CELLS IS INHIBITED BY THE ANTIANGIOGENIC FACTOR 16-KDA N-TERMINAL FRAGMENT OF PROLACTIN

被引：196

作者：

DANGELO, G ^{[1
]}

STRUMAN, I ^{[1
]}

MARTIAL, J ^{[1
]}

WEINER, RI ^{[1
]}

机构：

[1] UNIV LIEGE,MOLEC BIOL LAB,B-4000 SART,BELGIUM

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 14期

关键词：

D O I：

10.1073/pnas.92.14.6374

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A number of factors both stimulating and inhibiting angiogenesis have been described, In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiangiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.

引用

页码：6374 / 6378

页数：5

共 42 条

[1] REQUIREMENT FOR INTEGRATION OF SIGNALS FROM 2 DISTINCT PHOSPHORYLATION PATHWAYS FOR ACTIVATION OF MAP KINASE [J].