PREDICTING COILED COILS BY USE SF PAIRWISE RESIDUE CORRELATIONS

被引：577

作者：

BERGER, B

WILSON, DB

WOLF, E

TONCHEV, T

MILLA, M

KIM, PS

机构：

[1] MIT,COMP SCI LAB,CAMBRIDGE,MA 02139

[2] MIT,WHITEHEAD INST BIOMED RES,HOWARD HUGHES MED INST,DEPT BIOL,CAMBRIDGE,MA 02142

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 18期

关键词：

D O I：

10.1073/pnas.92.18.8259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A method is presented that predicts coiled-coil domains in protein sequences by using pairwise residue correlations obtained from a (two-stranded) coiled-coil database of 58,217 amino acid residues. A program called PAIRCOIL implements this method and is significantly better than existing methods at distinguishing coiled coils from alpha-helices that are not coiled coils, The database of pairwise residue correlations suggests structural features that stabilize or destabilize coiled coils.

引用

页码：8259 / 8263

页数：5

共 41 条

[1]

ANDREASSEN K, 1988, COMPUTER CRYPTOLOGY

[2]

[Anonymous], 1994, PROGRAM MANUAL WISCO

[3]

Berger B, 1995, J Comput Biol, V2, P125, DOI 10.1089/cmb.1995.2.125

[4] A METHOD TO IDENTIFY PROTEIN SEQUENCES THAT FOLD INTO A KNOWN 3-DIMENSIONAL STRUCTURE [J].