SYNTHETIC POLYMERIC SIALOSIDE INHIBITORS OF INFLUENZA-VIRUS RECEPTOR-BINDING ACTIVITY

被引：127

作者：

MATROSOVICH, MN ^{[1
]}

MOCHALOVA, LV ^{[1
]}

MARININA, VP ^{[1
]}

BYRAMOVA, NE ^{[1
]}

BOVIN, NV ^{[1
]}

机构：

[1] MM SHEMYAKIN BIOORGAN CHEM INST,MOSCOW 117871,USSR

来源：

FEBS LETTERS | 1990年 / 272卷 / 1-2期

关键词：

Antiviral drug; Fetuin; Influenza virus; Inhibitor of hemagglutination; Sialic acid; Virus attachment inhibitor;

D O I：

10.1016/0014-5793(90)80486-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anomeric aminobenzylglycosides of Neu5Ac were coupled with the polyacrylate carrier and a number of synthetic polyvalent sialosides obtained were investigated as inhibitors of influenza virus attachment. The inhibitory activity of polymeric sialosides is highly dependent upon the Neu5Ac residue content and the nature of the carrier. The polyacrylic acid based polymer bearing 10 mol% of Neu5Ac is 3 orders of magnitude more potent inhibitor than the corresponding monovalent benzylsialoside and considerably more active than fetuin. © 1990.

引用

页码：209 / 212

页数：4

共 13 条

[1] PERIODATE OR GLUTARALDEHYDE FOR PREPARING PEROXIDASE CONJUGATES [J].