A HEPARIN-BINDING GROWTH-FACTOR SECRETED BY MACROPHAGE-LIKE CELLS THAT IS RELATED TO EGF

被引：1091

作者：

HIGASHIYAMA, S

ABRAHAM, JA

MILLER, J

FIDDES, JC

KLAGSBRUN, M

机构：

[1] CHILDRENS HOSP MED CTR,DEPT SURG RES,BOSTON,MA 02115

[2] CALIF BIOTECHNOL INC,MT VIEW,CA 94043

[3] HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT MOLEC PHARMACOL,BOSTON,MA 02115

来源：

SCIENCE | 1991年 / 251卷 / 4996期

关键词：

D O I：

10.1126/science.1840698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.

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页码：936 / 939

页数：4

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