THE 3RS OF LIFE - RAS, RAF AND GROWTH-REGULATION

被引：155

作者：

MOODIE, SA

WOLFMAN, A

机构：

[1] S.A. Moodie and A. Wolfman are in the Department of Cell Biologie, Cleveland Clinic Foundation, Cleveland

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 02期

关键词：

D O I：

10.1016/0168-9525(94)90147-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cellular Ras proteins are essential elements in normal signal transduction pathways while activated Ras proteins are prevalent in many different forms of human cancers. Here, we discuss the mechanism through which Ras proteins, either cellular or activated, transmit a proliferative signal by activating cytoplasmic serine/threonine kinases.

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页码：44 / 48

页数：5

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