CYCLIN IS A COMPONENT OF MATURATION-PROMOTING FACTOR FROM XENOPUS

被引：590

作者：

GAUTIER, J

MINSHULL, J

LOHKA, M

GLOTZER, M

HUNT, T

MALLER, JL

机构：

[1] UNIV COLORADO,SCH MED,DEPT PHARMACOL,DENVER,CO 80262

[2] UNIV COLORADO,SCH MED,DEPT CELLULAR & STRUCT BIOL,DENVER,CO 80262

[3] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND

来源：

CELL | 1990年 / 60卷 / 03期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0092-8674(90)90599-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly purified maturation-promoting factor (MPF) from Xenopus eggs contains both cyclin B1 and cyclin B2 as shown by Western blotting and immunoprecipitation using Xenopus anti-B-type cyclin antibodies. Immunoprecipitates with these antibodies display the histone H1 kinase activity characteristic of MPF, for which exogenously added B1 and B2 cyclins are both substrates. Protein kinase activity against cyclin oscillates in maturing oocytes and activated eggs with the same kinetics as p34cdc2 kinase activity. These data indicate that B-type cyclin is the other component of MPF besides p34cdc2. © 1990.

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页码：487 / 494

页数：8

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