NATURAL HIV-1 NEF ACCELERATES VIRUS-REPLICATION IN PRIMARY HUMAN-LYMPHOCYTES

被引：158

作者：

DERONDE, A

KLAVER, B

KEULEN, W

SMIT, L

GOUDSMIT, J

机构：

[1] Human Retrovirus Laboratory, University of Amsterdam, Academic Medical Centre, 1105 AZ Amsterdam

来源：

VIROLOGY | 1992年 / 188卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)90772-H

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines. © 1992.

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页码：391 / 395

页数：5

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