EFFECT OF ACUTE AND CHRONIC NALOXONE ADMINISTRATION ON MOTOR ACTIVATION IN THE RAT

被引：59

作者：

AMIR, S

SOLOMON, M

AMIT, Z

机构：

[1] Center for Research on Drug Dependence, Department of Psychology, Concordia University, Montreal, Que. H3G 1M8

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 02期

关键词：

D O I：

10.1016/0028-3908(79)90058-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The acute and chronic effects of naloxone on motor activity was studied in rats. No difference in motor activity was noted between naloxone-treated (2.5, 5.0, 10.0 mg/kg) and saline-treated rats on the first day of testing. By contrast, naloxone, in all three doses tested, blocked the increase in motor activation noted in saline-treated animals upon repeated testing. These data may suggest that endogenous opioid systems may play a role in behavioral activation and adaptation and provide further support to the proposed involvement of endogenous ligands for the opiate receptor in emotional reactivity. © 1979.

引用

页码：171 / 173

页数：3

共 22 条

[1]

BERNEY S, 1977, COMMUN PSYCHOPHARMAC, V1, P597

[2] NALOXONE AND MORPHINE EFFECTS ON SENSORY-EVOKED RESPONSES [J].