DECREASED 5-HT-MEDIATED PROLACTIN-RELEASE IN MAJOR DEPRESSION

被引:54
作者
ANDERSON, IM
WARE, CJ
DAVIS, JMD
COWEN, PJ
机构
[1] LITTLEMORE HOSP, MRC, CLIN PHARMACOL UNIT, OXFORD, ENGLAND
[2] UNIV OXFORD, DEPT PSYCHIAT, OXFORD OX4 4XN, ENGLAND
关键词
D O I
10.1192/bjp.160.3.372
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.
引用
收藏
页码:372 / 378
页数:7
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