VIP GENE-EXPRESSION IN RAT THYMUS AND SPLEEN

被引：44

作者：

GOMARIZ, RP

DELGADO, M

NARANJO, JR

MELLSTROM, B

TORMO, A

MATA, F

LECETA, J

机构：

[1] UNIV COMPLUTENSE,FAC QUIM,DEPT BIOQUIM & BIOL MOLEC 1,E-28040 MADRID,SPAIN

[2] CSIC,INST CAJAL,E-28002 MADRID,SPAIN

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1993年 / 7卷 / 04期

关键词：

D O I：

10.1006/brbi.1993.1027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vasoactive intestinal peptide (VIP) is a neuropeptide with immunomodulatory properties. In the present study, we demonstrate VIP gene expression in cells of both thymus and spleen in the rat by in situ hybridization. In thymus sections, hybridization signal for VIP mRNA was found in cells in corticomedullary and medulla regions. In the spleen, cells were labeled at the outer area on the periarteriolar lymphoid sheath of the white pulp. Hybridization signal appeared to be in lymphoid cells. These findings suggest that lymphoid cells might produce VIP, which, if released, could exert a paracrine action on central and peripheral lymphoid organs. We suggest that VIP participates in the bidirectional communication between the nervous and the immune systems. © 1993 Academic Press, Inc.

引用

页码：271 / 278

页数：8

共 32 条

[1] INTERACTIONS BETWEEN THE BRAIN AND THE IMMUNE-SYSTEM [J].