SEXUAL STAGE DEVELOPMENT OF CRYPTOSPORIDIA IN THE CACO-2 CELL-LINE

被引：49

作者：

BURAUD, M

FORGET, E

FAVENNEC, L

BIZET, J

GOBERT, JG

DELUOL, AM

机构：

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 12期

关键词：

D O I：

10.1128/IAI.59.12.4610-4613.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used the spontaneously differentiated human intestinal epithelial cell line Caco-2 to develop an in vitro model of Cryptosporidium sp. infection. The mean cell infection rate was 3% +/- 2%. Asexual stages of cryptosporidia were observed on day 2 postinoculation. Transmission electron microscopy showed the presence of macrogametes at day 5. This cell line appears to be suited to the study of the mechanisms by which biological agents inhibit both sexual and asexual development of cryptosporidia.

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页码：4610 / 4613

页数：4

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