WIDESPREAD INCREASE OF NERVE GROWTH-FACTOR PROTEIN IN THE RAT FOREBRAIN AFTER KINDLING-INDUCED SEIZURES

被引：79

作者：

BENGZON, J

SODERSTROM, S

KOKAIA, Z

KOKAIA, M

ERNFORS, P

PERSSON, H

EBENDAL, T

LINDVALL, O

机构：

[1] KAROLINSKA INST,DEPT MED CHEM,MOLEC NEUROBIOL LAB,S-10401 STOCKHOLM 60,SWEDEN

[2] UNIV UPPSALA,CTR BIOMED,DEPT DEV BIOL,S-75105 UPPSALA,SWEDEN

来源：

BRAIN RESEARCH | 1992年 / 587卷 / 02期

关键词：

NERVE GROWTH FACTOR; KINDLING; EPILEPSY; PLASTICITY; HIPPOCAMPUS; PIRIFORM CORTEX; PARIETAL CORTEX;

D O I：

10.1016/0006-8993(92)91016-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.

引用

收藏

页码：338 / 342

页数：5

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