THE SON OF SEVENLESS GENE-PRODUCT - A PUTATIVE ACTIVATOR OF RAS

被引：251

作者：

BONFINI, L

KARLOVICH, CA

DASGUPTA, C

BANERJEE, U

机构：

[1] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

SCIENCE | 1992年 / 255卷 / 5044期

关键词：

D O I：

10.1126/science.1736363

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595 - amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.

引用

页码：603 / 606

页数：4

共 23 条

[1]

ASHBURNER M, 1991, DROS INF SER, V69, P1

[2] MOLECULAR CHARACTERIZATION AND EXPRESSION OF SEVENLESS, A GENE INVOLVED NEURONAL PATTERN-FORMATION IN THE DROSOPHILA EYE [J].