GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS

被引：2794

作者：

LIN, LFH ^{[1
]}

DOHERTY, DH ^{[1
]}

LILE, JD ^{[1
]}

BEKTESH, S ^{[1
]}

COLLINS, F ^{[1
]}

机构：

[1] SYNERGEN INC,1885 33RD ST,BOULDER,CO 80301

来源：

SCIENCE | 1993年 / 260卷 / 5111期

关键词：

D O I：

10.1126/science.8493557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

引用

页码：1130 / 1132

页数：3

共 30 条

[1] EVOLUTIONARY GROUPING OF THE TRANSFORMING GROWTH-FACTOR-BETA SUPERFAMILY [J].