THERAPY-RELATED ACUTE PROMYELOCYTIC LEUKEMIA

被引：26

作者：

BHAVNANI, M ^{[1
]}

AZZAWI, SA ^{[1
]}

YIN, JAL ^{[1
]}

LUCAS, GS ^{[1
]}

机构：

[1] MANCHESTER ROYAL INFIRM,DEPT CLIN HAEMATOL,MANCHESTER M13 9WL,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 01期

关键词：

SECONDARY LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; DNA TOPOISOMERASE II; FAVORABLE CYTOGENETICS;

D O I：

10.1111/j.1365-2141.1994.tb03288.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report three patients with acute promyelocytic leukaemia (APL) occurring after treatment for other malignant disorders. One patient had had razoxane (a drug affecting DNA topoisomerase II) for cancer of the colon, and the other two had had treatment for cancer of the breast. Two out of the three patients went into complete remission. We review the published literature on therapy-related acute promyelocytic leukaemia (t-APL) and suggest that it is a genuine clinical entity which may be caused by drugs affecting DNA topoisomerase II, and has a prognosis similar to de novo APL.

引用

页码：231 / 232

页数：2

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