MOLECULAR-GENETICS OF WILMS-TUMOR

被引：10

作者：

GRUNDY, P

COPPES, MJ

HABER, D

机构：

[1] CROSS CANC INST, MOLEC ONCOL PROGRAM, 11560 UNIV AVE, EDMONTON, AB T6G 1Z2, CANADA

[2] UNIV ALBERTA, EDMONTON, AB, CANADA

[3] UNIV CALGARY, TOM BAKER CANC CTR, CALGARY, AB, CANADA

[4] ALBERTA CHILDRENS PROV GEN HOSP, CALGARY, AB T2T 5C7, CANADA

[5] HARVARD UNIV, SCH MED, BOSTON, MA USA

[6] HARVARD UNIV, SCH MED, BOSTON, MA USA

[7] MASSACHUSETTS GEN HOSP, CTR CANC, BOSTON, MA USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1995年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0889-8588(18)30041-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The study of Wilms tumor-predisposing congenital syndromes has led to the identification of one tumor-suppresser gene, WT1, and to the localization of WT2. Molecular genetic analyses of these and sporadic Wilms tumors have clarified the role of WT1 in Wilms tumor with aniridia, genitourinary malformations, and mental retardation (WAGR)-syndrome patients, but much remains unclear in the case of WT2 and the Beckwith-Wiedemann syndrome. Loci on chromosomes 16q and 1p have now been implicated in the progression of Wilms tumor and may serve as molecular prognostic markers. It is now clear that Wilms tumors are genetically heterogeneous and may be multigenic in origin. Molecular analyses can now be used for genetic counseling in some children and may become useful in individualizing therapy.

引用

页码：1201 / +

页数：1

共 77 条

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