DEVELOPMENTAL-CHANGES IN DISTRIBUTION OF NMDA RECEPTOR CHANNEL SUBUNIT MESSENGER-RNAS

被引：618

作者：

WATANABE, M ^{[1
]}

INOUE, Y ^{[1
]}

SAKIMURA, K ^{[1
]}

MISHINA, M ^{[1
]}

机构：

[1] NIIGATA UNIV,INST BRAIN RES,DEPT NEUROPHARMACOL,NIIGATA 951,JAPAN

来源：

NEUROREPORT | 1992年 / 3卷 / 12期

关键词：

NMDA RECEPTOR CHANNEL; GLUTAMATE RECEPTOR CHANNEL; EPSILON SUBUNIT FAMILY; ZETA SUBUNIT; BRAIN; DEVELOPMENT; INSITU HYBRIDIZATION; MOUSE;

D O I：

10.1097/00001756-199212000-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IN SITU hybridization analyses have revealed drastic changes in expression and distribution of five subunit mRNAs of the mouse NMDA receptor channel during brain development. The epsilon1 subunit mRNA is expressed postnatally and widely in the brain. On the other hand, the epsilon2 subunit mRNA is found throughout the entire embryonic brain, but its expression becomes restricted to the forebrain at postnatal stages. The epsilon3 subunit mRNA appears postnatally and predominantly in the cerebellum, whereas the epsilon4 subunit MRNA is abundantly expressed in the diencephalon and the brainstem at embryonic and neonatal stages. In contrast, the zeta1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development.

引用

页码：1138 / 1140

页数：3

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