THE DAF-4 GENE ENCODES A BONE MORPHOGENETIC PROTEIN-RECEPTOR CONTROLLING C-ELEGANS DAUER LARVA DEVELOPMENT

被引：333

作者：

ESTEVEZ, M

ATTISANO, L

WRANA, JL

ALBERT, PS

MASSAGUE, J

RIDDLE, DL

机构：

[1] UNIV MISSOURI,DIV BIOL SCI,COLUMBIA,MO 65211

[2] MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,CELL BIOL & GENET PROGRAM,NEW YORK,NY 10021

来源：

NATURE | 1993年 / 365卷 / 6447期

关键词：

D O I：

10.1038/365644a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth factor-beta (TGF-beta) superfamily1,2. This group, including the Drosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development3,4 . Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C elegans to form a developmentally arrested, third-stage dauer larva5. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-beta receptor serine/threonine kinases. When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.

引用

页码：644 / 649

页数：6

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