AMINO-ACID-SEQUENCE ANALYSIS OF A MOUSE INTERLEUKIN-5 RECEPTOR PROTEIN REVEALS HOMOLOGY WITH A MOUSE INTERLEUKIN-3 RECEPTOR PROTEIN

被引：9

作者：

DEVOS, R

VANDEKERCKHOVE, J

ROLINK, A

PLAETINCK, G

VANDERHEYDEN, J

FIERS, W

TAVERNIER, J

机构：

[1] STATE UNIV GHENT,GENET LAB,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT,MOLEC BIOL LAB,B-9000 GHENT,BELGIUM

[3] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 05期

关键词：

D O I：

10.1002/eji.1830210533

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A polypeptide chain for the mouse interleukin 5 receptor (IL5R) was purified from detergent-lysed B13 cells, a mouse IL5-dependent pre-B cell line. Purification was by a single immunoaffinity chromatographic step using an anti-mouse IL5R monoclonal antibody, R52. Internal amino acid sequence was obtained from four trypsin-generated peptides. All peptides were found to be present in the published amino acid sequence of a mouse IL3R and the mouse IL3R-like protein deduced from the cDNA. This indicates that the mouse IL5R and the mouse IL3R have a homologous polypeptide in common and suggests that the specificity of these lymphokine receptors is mainly generated by association with another ligand-specific polypeptide chain.

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页码：1315 / 1317

页数：3

相关论文

共 14 条

[1] BIOTINYLATION - AN ALTERNATIVE TO RADIOIODINATION FOR THE IDENTIFICATION OF CELL-SURFACE ANTIGENS IN IMMUNOPRECIPITATES [J].

COLE, SR ;

ASHMAN, LK ;

EY, PL .

MOLECULAR IMMUNOLOGY, 1987, 24 (07) :699-705

[2] CLONING AND EXPRESSION OF A GENE ENCODING AN INTERLEUKIN-3 RECEPTOR-LIKE PROTEIN - IDENTIFICATION OF ANOTHER MEMBER OF THE CYTOKINE RECEPTOR GENE FAMILY [J].

GORMAN, DM ;

ITOH, N ;

KITAMURA, T ;

SCHREURS, J ;

YONEHARA, S ;

YAHARA, I ;

ARAI, KI ;

MIYAJIMA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5459-5463

[3]

HITOSHI Y, 1990, J IMMUNOL, V144, P4218

[4] CLONING OF AN INTERLEUKIN-3 RECEPTOR GENE - A MEMBER OF A DISTINCT RECEPTOR GENE FAMILY [J].

ITOH, N ;

YONEHARA, S ;

SCHREURS, J ;

GORMAN, DM ;

MARUYAMA, K ;

ISHII, A ;

YAHARA, I ;

ARAI, K ;

MIYAJIMA, A .

SCIENCE, 1990, 247 (4940) :324-327

[5] RECEPTORS FOR T-CELL-REPLACING FACTOR INTERLEUKIN-5 - SPECIFICITY, QUANTITATION, AND ITS IMPLICATION [J].

MITA, S ;

HARADA, N ;

NAOMI, S ;

HITOSHI, Y ;

SAKAMOTO, K ;

AKAGI, M ;

TOMINAGA, A ;

TAKATSU, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (03) :863-878

[6] CHARACTERIZATION OF HIGH-AFFINITY RECEPTORS FOR INTERLEUKIN-5 ON INTERLEUKIN-5-DEPENDENT CELL-LINES [J].

MITA, S ;

TOMINAGA, A ;

HITOSHI, Y ;

SAKAMOTO, K ;

HONJO, T ;

AKAGI, M ;

KIKUCHI, Y ;

YAMAGUCHI, N ;

TAKATSU, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2311-2315

[7] CHARACTERIZATION OF INTERLEUKIN-5 RECEPTORS ON EOSINOPHILIC SUBLINES FROM HUMAN PROMYELOCYTIC LEUKEMIA (HL-60) CELLS [J].

PLAETINCK, G ;

VANDERHEYDEN, J ;

TAVERNIER, J ;

FACHE, I ;

TUYPENS, T ;

FISCHKOFF, S ;

FIERS, W ;

DEVOS, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) :683-691

[8] MONOCLONAL-ANTIBODIES REACTIVE WITH THE MOUSE INTERLEUKIN-5 RECEPTOR [J].

ROLINK, AG ;

MELCHERS, F ;

PALACIOS, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (05) :1693-1701

[9] THE BIOLOGICAL ROLE OF INTERLEUKIN-5 [J].

SANDERSON, CJ .

INTERNATIONAL JOURNAL OF CELL CLONING, 1990, 8 :147-154

[10]

SCHNEIDER C, 1982, J BIOL CHEM, V257