SPECIFIC-INHIBITION OF MACROPHAGE-MIGRATION INHIBITION-FACTOR BY FUCOSYLATED GLYCOLIPID RM

被引：13

作者：

MIURA, T ^{[1
]}

HANDA, S ^{[1
]}

YAMAKAWA, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT BIOCHEM,TOKYO 113,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a132583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of glycolipids on the interaction of the MIF (migration inhibition factor) with rat macrophages were examined using a migration inhibition assay system. MIF activity was specifically blocked by fucosylated Glycolipid RM [Galα1-3Gal(2-lαFuc)β1-3GalNAcβ1-3Galβ1-4Glcβ1-1ceramide, (1978) J. Biochem. 83, 85-90], but not by Cytolipin R, hematoside, or blood group B active glycolipid [Galα1-3Gal(2-1αFuc)β1-4GlcNAcβ1-3Galβ1-4Glcβ1-1ceramide]. Inhibition of MIF activity was proportional to the concentration of Glycolipid RM. These findings suggest that Glycolipid RM acts as a receptor for MIF. © 1979 by The Journal of Biochemistry.

引用

页码：773 / 776

页数：4

共 16 条

[1]

ANDO S, 1973, J BIOCHEM-TOKYO, V73, P387

[2]

BOYUM A, 1968, SCAND J CLIN LAB S97, V21, P1

[3] CELLULAR HYPERSENSITIVITY AND IMMUNITY - INHIBITION OF MACROPHAGE MIGRATION AND LYMPHOCYTE MEDIATORS [J].