GTPASE INHIBITING MUTATIONS ACTIVATE THE ALPHA-CHAIN OF GS AND STIMULATE ADENYLYL CYCLASE IN HUMAN PITUITARY-TUMORS

被引:1308
作者
LANDIS, CA
MASTERS, SB
SPADA, A
PACE, AM
BOURNE, HR
VALLAR, L
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT MED,DIV RENAL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143
[4] UNIV MILAN,SCI INST SAN RAFFAELE,CNR,CTR CYTOPHARMACOL,DEPT PHARMACOL,I-20122 MILAN,ITALY
[5] UNIV MILAN,SCH MED,DEPT ENDOCRINOL,I-20122 MILAN,ITALY
关键词
D O I
10.1038/340692a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:692 / 696
页数:5
相关论文
共 39 条
[1]   GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN (GAP) INTERACTS WITH THE P21-RAS EFFECTOR BINDING DOMAIN [J].
ADARI, H ;
LOWY, DR ;
WILLUMSEN, BM ;
DER, CJ ;
MCCORMICK, F .
SCIENCE, 1988, 240 (4851) :518-520
[2]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[3]   GROWTH HORMONE-RELEASING FACTOR STIMULATES PROLIFERATION OF SOMATOTROPHS INVITRO [J].
BILLESTRUP, N ;
SWANSON, LW ;
VALE, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6854-6857
[4]  
BIRNBAUMER L, 1987, KIDNEY INT, V32, pS14
[5]   DISCOVERY OF A NEW ONCOGENE IN PITUITARY-TUMORS [J].
BOURNE, HR .
NATURE, 1987, 330 (6148) :517-518
[6]  
CASEY PJ, 1988, J BIOL CHEM, V263, P2577
[7]  
CASSEL D, 1979, J BIOL CHEM, V254, P9835
[8]   MECHANISM OF ADENYLATE-CYCLASE ACTIVATION BY CHOLERA TOXIN - INHIBITION OF GTP HYDROLYSIS AT REGULATORY SITE [J].
CASSEL, D ;
SELINGER, Z .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3307-3311
[9]  
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[10]   BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF HUMAN RASH GENES MUTATED AT CODON-61 [J].
DER, CJ ;
FINKEL, T ;
COOPER, GM .
CELL, 1986, 44 (01) :167-176