CLONIDINE AND SCOPOLAMINE - DIFFERENCES AND SIMILARITIES IN HOW THEY CHANGE HUMAN INFORMATION-PROCESSING

被引：15

作者：

CALLAWAY, E

HALLIDAY, R

NAYLOR, H

BRANDEIS, D

机构：

[1] San Francisco Veterans Administration Medical Center San Francisco, CA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1991年 / 15卷 / 04期

关键词：

AVERAGED EVENT RELATED POTENTIALS; CLONIDINE; INFORMATION PROCESSING; REACTION TIME; SCOPOLAMINE;

D O I：

10.1016/0278-5846(91)90024-U

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Humans have been tested on a choice reaction time task designed to disclose interactions between stimulus complexity and drug effect. 2. Tests were carried out using oral scopolamine (1.2 mg) and clonidine (0.2 mg). 3. Reaction times and event related potentials were measured. 4. Both drugs slowed reaction time and the N1 component of the ERP. 5. SCOP slows RTs to easy-to-discriminate stimuli more than RTs to harder stimuli. Its effect on P3 is the same for both types of stimuli. 6. CLON tends to slow P3 latencies to easy stimuli more than P3 latencies to harder stimuli, while the RT slowing is almost identical for both types of stimuli,

引用

页码：497 / 502

页数：6

共 17 条

[1]

BRANDEIS D, 1990, PSYCHOPHYSIOLOGICAL

[2]

BUCCAFUSCO JJ, 1988, PHARM BIOCHEM BEHAVI, V29, P15

[3] EFFECTS OF ORAL SCOPOLAMINE ON HUMAN STIMULUS EVALUATION [J].