AUGMENTATION OF HAPTOGLOBIN PRODUCTION IN HEP3B CELL-LINE BY A NUCLEAR FACTOR NF-IL6

被引：35

作者：

NATSUKA, S ^{[1
]}

ISSHIKI, H ^{[1
]}

AKIRA, S ^{[1
]}

KISHIMOTO, T ^{[1
]}

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,1-3 YAMADA OKA,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1991年 / 291卷 / 01期

关键词：

ACUTE PHASE PROTEIN; NF-IL6; INTERLEUKIN-6; GENE EXPRESSION; HAPTOGLOBIN; HEPATOCYTE;

D O I：

10.1016/0014-5793(91)81103-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear factor NF-IL6 had been suggested to be responsible for the IL-6-mediated induction of several acute-phase proteins. To obtain evidence for the involvement of NF-IL6 in the induction of acute-phase proteins, we introduced the NF-IL6 gene and its truncated mutant (delNFIL6) gene into a hepatoma cell line Hep3B. Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin. As a result, basal production as well as induction of haptoglobin by IL-6 were augmented by the expression of NF-IL6, whereas delNFIL6 blocked the production of haptoglobin, fibrinogen and albumin.

引用

页码：58 / 62

页数：5

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