EFFECT OF ACUTE AND CHRONIC ETHANOL INTAKE ON HEPATIC GLYCEROLIPID BIOSYNTHESIS IN THE HAMSTER

被引：43

作者：

LAMB, RG ^{[1
]}

WOOD, CK ^{[1
]}

FALLON, HJ ^{[1
]}

机构：

[1] MED COLL VIRGINIA, DEPT MED, RICHMOND, VA 23298 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 63卷 / 01期

关键词：

D O I：

10.1172/JCI109268

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of this enzyme.

引用

页码：14 / 20

页数：7

共 40 条

[1] INHIBITION OF HEPATIC TRIGLYCERIDE FORMATION BY CLOFIBRATE [J].