RABIES VIRUSES INCREASE IN VIRULENCE WHEN PROPAGATED IN NEUROBLASTOMA CELL-CULTURE

被引：45

作者：

CLARK, HF

机构：

[1] Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104

来源：

SCIENCE | 1978年 / 199卷 / 4333期

关键词：

D O I：

10.1126/science.628831

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.

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页码：1072 / 1075

页数：4

相关论文

共 36 条

[1] ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMA [J].

AUGUSTIT.G ;

SATO, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 64 (01) :311-&

[2] STUDIES OF IMMUNOGENICITY COMMUNICABILITY AND GENETIC STABILITY OF ORAL POLIOVACCINE ADMINISTERED DURING WINTER [J].

BENYESHM.M ;

MELNICK, JL ;

RAWLS, WE ;

WIMBERLY, I ;

ORO, JB ;

BENPORAT.E ;

RENNICK, V .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1967, 86 (01) :112-&

[3]

BIEDLER JL, 1973, CANCER RES, V33, P2643

[4] NEUROTRANSMITTER METABOLISM IN MURINE NEUROBLASTOMA-CELLS [J].

BREAKEFIELD, XO .

LIFE SCIENCES, 1976, 18 (03) :267-278

[5]

CLARK H, UNPUBLISHED

[6] ISOLATION OF TEMPERATURE-SENSITIVE CONDITIONAL LETHAL MUTANTS OF FIXED RABIES VIRUS [J].

CLARK, HF ;

KOPROWSKI, H .

JOURNAL OF VIROLOGY, 1971, 7 (03) :295-+

[7] TEMPERATURE-SENSITIVITY CHARACTERISTICS DISTINGUISHING SUBSTRAINS OF FIXED RABIES VIRUS - LACK OF CORRELATION WITH PLAQUE-SIZE MARKERS OR VIRULENCE FOR MICE [J].

CLARK, HF ;

WIKTOR, TJ .

JOURNAL OF INFECTIOUS DISEASES, 1972, 125 (06) :637-+

[8]

CLARK HF, 1972, STRAINS HUMAN VIRUSE, P177

[9] ISOLATION OF A TEMPERATURE-SENSITIVE DENGUE-2 VIRUS UNDER CONDITIONS SUITABLE FOR VACCINE DEVELOPMENT [J].

ECKELS, KH ;

BRANDT, WE ;

HARRISON, VR ;

MCCOWN, JM ;

RUSSELL, PK .

INFECTION AND IMMUNITY, 1976, 14 (05) :1221-1227

[10] CORRELATION BETWEEN TS PHENOTYPE AND PATHOGENICITY OF SOME ANIMAL VIRUSES [J].

GHENDON, YZ ;

MARCHENKO, AT ;

MARKUSHIN, SG ;

GHENKINA, DB ;

MIKHEJEVA, AV ;

ROZINA, EE .

ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG, 1973, 42 (02) :154-159

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