INFLUENCE OF AGE, SEX AND DRUG TREATMENT ON MICROSOMAL DRUG METABOLISM IN 4 RAT STRAINS

被引：60

作者：

FURNER, RL

GRAM, TE

STITZEL, RE

机构：

[1] Department of Pharmacology, College of Medicine, West Virginia University, Morgantown, W. Va.

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 07期

关键词：

D O I：

10.1016/0006-2952(69)90151-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study describes the influence of sex, age and drug pretreatment on drug metabolism in four common strains of rats. Basal levels of activity of hepatic microsomal drug-metabolizing enzymes in the four strains varied considerably less than those reported in different rabbit and mouse strains. There was, in general, only a 2-fold variation in metabolic rate for a single drug. Young male and female Holtzman rats showed the lowest microsomal metabolism in all drug pathways examined. Phenobarbital pretreatment caused a stimulation of drug metabolism in young and adult, male and female rats of all strains. 3-Methylcholanthrene, on the other hand, often caused no change or decreased the rate. Evidence is presented which suggests that liver microsomes may contain a number of NADPH-dependent enzymes which differ in their rates of postpubertal development. © 1969.

引用

页码：1635 / &

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