ELECTRON-AFFINIC SENSITIZATION .I. A STRUCTURAL BASIS FOR CHEMICAL RADIOSENSITIZERS IN BACTERIA

被引：244

作者：

ADAMS, GE

COOKE, MS

机构：

[1] British Empire Cancer Campaign for Research, Research Unit in Radiobiology, Mount Vernon Hospital, Northwood, Middlesex, England

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 15卷 / 05期

关键词：

D O I：

10.1080/09553006914550741

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The bacterium Serratia marcescens has been used as a test system for demonstrating the radiosensitizing properties of a class of electron-affinic organic compounds. These include: unsaturated diesters and diketo compounds, mono-, di- and triketohydrindene (indanetrione), derivatives of pyruvic acid, quinones and several miscellaneous compounds. With few exceptions, the sensitization is restricted to anoxic systems. An electron-transfer mechanism, involving interaction of the sensitizer with a charged intermediate produced by direct energy absorption in a target molecule, is proposed as the basis of a model for radiosensitization. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：457 / &

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