CORONARY VASOCONSTRICTION IN THE CONSCIOUS RABBIT FOLLOWING INTRAVENOUS-INFUSION OF L-NG-NITRO-ARGININE

被引：47

作者：

HUMPHRIES, RG

CARR, RD

NICOL, AK

TOMLINSON, W

OCONNOR, SE

机构：

[1] Department of Pharmacology, Fisons plc, Pharmaceutical Division, Loughborough, Leicestershire

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 102卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1991.tb12212.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intravenous infusion of L-N(G)-nitro-arginine, an inhibitor of endothelial nitric oxide (NO) synthesis, produced vasoconstriction in the coronary, cerebral, renal and duodenal vascular beds of the conscious rabbit. In this study, using radiolabelled microspheres, we provide in vivo evidence for a basal NO-dependent vasodilator tone in the coronary vascular bed.

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页码：565 / 566

页数：2

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