EFFECT OF THE FLAVANOLIGNANS OF SILYBUM-MARIANUM L ON LIPID-PEROXIDATION IN RAT-LIVER MICROSOMES AND FRESHLY ISOLATED HEPATOCYTES

被引：122

作者：

BOSISIO, E

BENELLI, C

PIROLA, O

机构：

[1] Institute of Pharmacological Sciences, Faculty of Pharmacy, University of Milan

来源：

PHARMACOLOGICAL RESEARCH | 1992年 / 25卷 / 02期

关键词：

FLAVANOLIGNANS; LIPID PEROXIDATION; MICROSOMES; HEPATOCYTES;

D O I：

10.1016/1043-6618(92)91383-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. In microsomes lipid peroxidation was generated by ADP/Fe2+ and NADPH. All flavanolignans inhibited peroxidation in a concentration dependent manner. In hepatocytes lipid peroxidation was induced by ADP/Fe3+ complex and cell damage was evaluated as LDH activity released in the medium. The inhibition of the peroxidative process by flavanolignans was also evident in this model, even if with a potency order different from that found in microsomes. In contrast, the effect on LDH release was significant only for silybin and isosilybin, the other compounds being inactive on this parameter. © 1992.

引用

页码：147 / 154

页数：8

共 31 条

[1]

Bergmeyer H.U., 1974, METHOD ENZYMAT AN, VVol. 3., P1196

[2] INHIBITORY ACTION OF SILYMARIN OF LIPID PEROXIDE FORMATION IN RAT-LIVER MITOCHONDRIA AND MICROSOMES [J].