SH3 - AN ABUNDANT PROTEIN DOMAIN IN SEARCH OF A FUNCTION

被引：268

作者：

MUSACCHIO, A

GIBSON, T

LEHTO, VP

SARASTE, M

机构：

[1] UNIV OULU,DEPT PATHOL,SF-90220 OULU,FINLAND

[2] UNIV OULU,BIOCTR,SF-90220 OULU,FINLAND

来源：

FEBS LETTERS | 1992年 / 307卷 / 01期

关键词：

SH3; STRUCTURAL PREDICTION; OCCURRENCE; FUNCTION;

D O I：

10.1016/0014-5793(92)80901-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.

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页码：55 / 61

页数：7

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