INHIBITION OF MITOCHONDRIAL RESPIRATION BY ANALOGS OF 4-PHENYLPYRIDINE AND 1-METHYL-4-PHENYLPYRIDINIUM CATION (MPP+), THE NEUROTOXIC METABOLITE OF MPTP

被引：86

作者：

HOPPEL, CL

GREENBLATT, D

KWOK, HC

ARORA, PK

SINGH, MP

SAYRE, LM

机构：

[1] VET ADM HOSP,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,DEPT PHARMACOL,CLEVELAND,OH 44106

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 148卷 / 02期

关键词：

D O I：

10.1016/0006-291X(87)90931-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：684 / 693

页数：10

共 66 条

[1] FACILE SYNTHESIS OF 4-SUBSTITUTED PYRIDINES USING GRIGNARD-REAGENTS [J].

AKIBA, K ;

ISEKI, Y ;

WADA, M .

TETRAHEDRON LETTERS, 1982, 23 (38) :3935-3936

[2]

ANSHER SS, 1986, BIOCHEM PHARMACOL, V19, P3359

[3]

ARORA PK, UNPUB

[4]

AZZONE GF, 1976, BIOCHIM BIOPHYS ACTA, V459, P96

[5] CONVERSION OF BIOMEMBRANE-PRODUCED ENERGY INTO ELECTRIC FORM .2. INTACT MITOCHONDRIA [J].

BAKEEVA, LE ;

GRINIUS, LL ;

JASAITIS, AA ;

KULIENE, VV ;

LEVITSKY, DO ;

LIBERMAN, EA ;

SEVERINA, II ;

SKULACHEV, VP .

BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 216 (01) :13-+

[6] IDENTIFICATION AND QUANTIFICATION OF 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE, 2-METHYL-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE, AND 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE AS INVIVO CONSTITUENTS OF RAT-BRAIN AND ADRENAL-GLAND [J].

BARKER, SA ;

HARRISON, REW ;

MONTI, JA ;

BROWN, GB ;

CHRISTIAN, ST .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (01) :9-17

[7]

Bashford C L, 1979, Methods Enzymol, V55, P569

[8] 1-METHYL-4-PHENYLPYRIDINE IS NEUROTOXIC TO THE NIGROSTRIATAL DOPAMINE PATHWAY [J].

BRADBURY, AJ ;

COSTALL, B ;

DOMENEY, AM ;

JENNER, P ;

KELLY, ME ;

MARSDEN, CD ;

NAYLOR, RJ .

NATURE, 1986, 319 (6048) :56-57

[9] EFFECTS OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE AND ITS METABOLITE 1-METHYL-4-PHENYLPYRIDINE ON ACETYLCHOLINE SYNTHESIS IN SYNAPTOSOMES FROM RAT FOREBRAIN [J].

CHEESEMAN, AJ ;

CLARK, JB .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (04) :1209-1214

[10] BETA-CARBOLINE ANALOGS OF N-METHYL-4-PHENYL-1,2,5,6-TETRA-HYDROPYRIDINE (MPTP) - ENDOGENOUS FACTORS UNDERLYING IDIOPATHIC PARKINSONISM [J].

COLLINS, MA ;

NEAFSEY, EJ .

NEUROSCIENCE LETTERS, 1985, 55 (02) :179-184

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