THE ROLE OF TRANSFORMING GROWTH-FACTOR-BETA IN HEMATOPOIESIS - A REVIEW

被引：58

作者：

HOOPER, WC

机构：

[1] Division of Immunologic, Oncologic, and Hematologic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 04期

关键词：

TRANSFORMING GROWTH FACTOR-BETA; HEMATOPOIETIC CELLS; CYTOKINES;

D O I：

10.1016/0145-2126(91)90118-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of TGFβ hematopoiesis is currently being defined. It does appear that TGFβ and related polypeptides [34-36] can modulate and regulate bone marrow and thymic-derived cells throughout their functional life span. The effects of TGFβ are pleiotropic and may depend on (a) cell lineage, (b) specific cellular phenotype, (c) stage of differentiation, (d) immediate microenvironment, (e) other cytokines and (f) cellular function. The understanding of TGFβ and its relationship to other cytokines should not only increase our understanding of hematopoiesis but may also have therapeutic implications. © 1991.

引用

页码：179 / 184

页数：6

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