HUMAN DIPLOID CELL TRANSFORMATION BY DNA EXTRACTED FROM TUMOR VIRUS SV40

被引：31

作者：

AARONSON, SA

TODARO, GJ

机构：

[1] Viral Carcinogenesis Branch, National Cancer Institute, Bethesda

来源：

SCIENCE | 1969年 / 166卷 / 3903期

关键词：

D O I：

10.1126/science.166.3903.390

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The DNA isolated from simian virus 40 (SV40) can transform human fibroblast cells in tissue culture. Clonal lines of DNA-transformed human cells have been obtained that have properties characteristic of cells transformed by whole virus. They all contain SV40 T-antigen, and infectious virus can be recovered by cocultivation. This is the first demonstration of a permanent genetic alteration produced in human cells by purified DNA.

引用

页码：390 / &

共 23 条

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