INCREASED FREQUENCY OF THE UNCOMMON ALLELE OF A TUMOR-NECROSIS-FACTOR-ALPHA GENE POLYMORPHISM IN RHEUMATOID-ARTHRITIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：112

作者：

DANIS, VA ^{[1
]}

MILLINGTON, M ^{[1
]}

HYLAND, V ^{[1
]}

LAWFORD, R ^{[1
]}

HUANG, QR ^{[1
]}

GRENNAN, D ^{[1
]}

机构：

[1] UNIV SYDNEY, DEPT RHEUMATOL, SYDNEY, NSW 2006, AUSTRALIA

来源：

DISEASE MARKERS | 1995年 / 12卷 / 02期

关键词：

TUMOR NECROSIS FACTOR; POLYMORPHISM; SLE; RA;

D O I：

10.1155/1994/756247

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population. In SLE patients, this allele was strongly associated with HLA-DR3 expression and was also more frequent in patients who did not have malar rash. Functional studies of normal monocyte cytokine production in vitro showed that this genotype was associated with increased IL-1 alpha protein production but there were no differences in the production of TNF alpha protein.

引用

页码：127 / 133

页数：7

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