INTRAVENTRICULAR NOREPINEPHRINE FACILITATES MOTOR RECOVERY FOLLOWING SENSORIMOTOR CORTEX INJURY

被引：169

作者：

BOYESON, MG

FEENEY, DM

机构：

[1] UNIV NEW MEXICO,DEPT PSYCHOL,ALBUQUERQUE,NM 87131

[2] UNIV NEW MEXICO,DEPT PHYSIOL,ALBUQUERQUE,NM 87131

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 03期

关键词：

Brain injury; Dopamine; Norepinephrine; Recovery of function; Sensorimotor cortex;

D O I：

10.1016/0091-3057(90)90279-Q

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Intraventricular norepinephrine, dopamine, or vehicle was administered to rats 24 hours after a unilateral sensorimotor cortex ablation to determine their potential roles in acceleration of motor recovery as measured by the beam-walking task. Norepinephrine was found to be the critical neurotransmitter in facilitating motor recovery. Blocking norepinephrine synthesis by dopamine-β-hydroxylase inhibition coupled with dopamine administration failed to accelerate recovery, indicating a more important role for norepinephrine compared to its precursor dopamine in motor recovery after sensorimotor cortex injury. © 1990.

引用

页码：497 / 501

页数：5

共 29 条

[1] FACILITATION OF MEMORY RETRIEVAL BY CENTRALLY ADMINISTERED CATECHOLAMINE STIMULATING AGENTS [J].