COPY CHOICE MECHANISM OF IMMUNOGLOBULIN HEAVY-CHAIN SWITCH RECOMBINATION

被引：54

作者：

DUNNICK, W ^{[1
]}

STAVNEZER, J ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT MOLEC GENET & MICROBIOL,WORCESTER,MA 01605

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 01期

关键词：

D O I：

10.1128/MCB.10.1.397

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.

引用

页码：397 / 400

页数：4

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