CONFIRMATION THAT MAGNESIUM LITHOSPERMATE-B HAS A HYDROXYL RADICAL-SCAVENGING ACTION

被引：50

作者：

YOKOZAWA, T ^{[1
]}

CHUNG, HY ^{[1
]}

DONG, E ^{[1
]}

OURA, H ^{[1
]}

机构：

[1] PUSAN NATL UNIV,DEPT PHARM,PUSAN 609735,SOUTH KOREA

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 1995年 / 47卷 / 05期

关键词：

MAGNESIUM LITHOSPERMATE B; HYDROXYL RADICAL; CREATININE; CREATOL; METHYLGUANIDINE;

D O I：

10.1016/S0940-2993(11)80344-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Male LWH: Wistar rats were given creatinine (Cr) intraperitoneally at a dose of 1.00 g/kg body weight, and the urine was collected for 3 h after administration. Magnesium lithospermate B, a compound newly isolated from Salviae Miltiorrhizae Radix, was administered intraperitoneally 30 min before and 30 min after Cr administration. The excretion of urinary creatol and methylguanidine induced by Cr decreased in a dose-dependent manner. Since we have already shown that the main contributor to the Cr-->creatol oxidation step is the hydroxyl radical, magnesium litho-spermate B may act as a radical scavenger.

引用

页码：341 / 344

页数：4

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