AN ENANTIODIVERGENT SYNTHESIS OF THREO BETA-AMINO ALCOHOLS - PREPARATION OF KEY INTERMEDIATES FOR BESTATIN AND THE RELATED PEPTIDES

被引：32

作者：

KAWABATA, T ^{[1
]}

KIRYU, Y ^{[1
]}

SUGIURA, Y ^{[1
]}

FUJI, K ^{[1
]}

机构：

[1] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)60694-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiodivergent method for preparation of threo beta-amino alcohols and threo 1,2-diamines has been developed starting with a chiral aziridine 1. Unusual amino acid derivatives 3 and 5, which are key synthetic intermediates for bestatin and the related peptides, have been prepared.

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收藏

页码：5127 / 5130

页数：4

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