PLASMA BETA-ENDORPHIN LEVELS IN CHRONIC-ALCOHOLICS

被引：42

作者：

AGUIRRE, JC ^{[1
]}

DELARBOL, JL ^{[1
]}

RAYA, J ^{[1
]}

RUIZREQUENA, ME ^{[1
]}

IRLES, JR ^{[1
]}

机构：

[1] HOSP UNIV SAN CECILIO,FAC MED,DEPT BIOCHEM,GRANADA,SPAIN

来源：

ALCOHOL | 1990年 / 7卷 / 05期

关键词：

Chronic alcoholic; Ethanol; Opioid system; Tetrahydroisoquinolines (TIQs); β-Endorphin;

D O I：

10.1016/0741-8329(90)90024-7

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

In order to test the possible relationship between the chronic consumption of alcohol and the opioid system, we have measured the plasma levels of β-endorphin in a group of 31 alcoholic patients and compared the results with those of a control group of 16 subjects. Our results show that chronic consumption of alcohol induces a significant decrease in β-endorphin (β-end) plasma levels regardless of either the disease suffered by the alcoholic patient or of the time of abstinence studied (one month maximum). Thus we believe that the β-end decrease may well be due to the patients' alcoholism and that it might be mediated by the tetrahydroisoquinoline system, or be a cause of alcoholism rather than a consequence. © 1990.

引用

页码：409 / 412

页数：4

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