CAPSAZEPINE INHIBITS LOW PH-EVOKED AND LACTIC ACID-EVOKED RELEASE OF CALCITONIN GENE-RELATED PEPTIDE FROM SENSORY NERVES IN GUINEA-PIG HEART

被引：54

作者：

FRANCOCERECEDA, A

LUNDBERG, JM

机构：

[1] Department of Pharmacology, Karolinska Institutet, 10401 Stockholm

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 01期

关键词：

CGRP (CALCITONIN GENE-RELATED PEPTIDE); CAPSAZEPINE; CARDIAC NERVES;

D O I：

10.1016/0014-2999(92)90792-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the isolated perfused guinea-pig heart low-pH buffer (pH 5), lactic acid (5 mM), capsaicin (10(-7) M) and nicotine (10(-4) M) all evoked a clear-cut release of calcitonin gene-related peptide (CGRP) from sensory nerves. Incubation with the proposed capsaicin receptor antagonist, capsazepine (10(-5) M), significantly reduced the CGRP release evoked not only by capsaicin but also by low pH and lactic acid, indicating a common mechanism of C-fibre activation, while the nicotine response remained unchanged.

引用

页码：183 / 184

页数：2

共 8 条

[1]

BEVAN S, 1990, TRENDS PHARMACOL SCI, V11, P330

[2] SELECTIVE ANTAGONISM OF CAPSAICIN BY CAPSAZEPINE - EVIDENCE FOR A SPINAL RECEPTOR-SITE IN CAPSAICIN-INDUCED ANTINOCICEPTION [J].