N,O-DIACYLATED-N-HYDROXYARYLSULFONAMIDES - NITROXYL PRECURSORS WITH POTENT SMOOTH-MUSCLE RELAXANT PROPERTIES

被引：42

作者：

FUKUTO, JM

HSZIEH, R

GULATI, P

CHIANG, KT

NAGASAWA, HT

机构：

[1] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55417

[2] VET ADM MED CTR,MED RES LABS,MINNEAPOLIS,MN 55417

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90453-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37°C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in vitro, presumably as a result of their ability to release HNO. This effect was enhanced by the addition of superoxide dismutase (SOD). Thus, these results are consistent with previous work indicating that HNO is a potent vasorelaxant. © 1992.

引用

页码：1367 / 1373

页数：7

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[2]

BRAKER WJ, 1971, MATHESON GAS DATA BO, P431

[3] PHOTOLYSIS OF NITROMETHANE AND OF METHYL NITRITE IN AN ARGON MATRIX - INFRARED DETECTION OF NITROXYL, HNO [J].