MUSCARINIC RECEPTOR ACTIVATION FACILITATES THE INDUCTION OF LONG-TERM POTENTIATION (LTP) IN THE RAT DENTATE GYRUS

被引：162

作者：

BURGARD, EC ^{[1
]}

SARVEY, JM ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI, DEPT PHARMACOL, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA

来源：

NEUROSCIENCE LETTERS | 1990年 / 116卷 / 1-2期

关键词：

Electrophysiology; Hippocampal formation; Long-term potentiation; M[!sub]1[!/sub] receptor; Muscarinic; Pirenzepine;

D O I：

10.1016/0304-3940(90)90382-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices. A concentration of 1 μM muscarine did not affect the evoked population spike or excitatory postsynaptic potential (EPSP), but facilitated the induction of LTP. In contrast, a concentration of 10 μM muscarine depressed both the population spike and EPSP, but had no effect on LTP induction. The M1 muscarinic receptor antagonist pirenzepine (1 μM) blocked the muscarine-induced facilitation of LTP, but had no effect on the depression of evoked responses. These data suggest that activation of M1 receptors can facilitate the induction of LTP. © 1990.

引用

页码：34 / 39

页数：6

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