DETECTION OF THE PHILADELPHIA-CHROMOSOME IN INTERPHASE NUCLEI

被引：180

作者：

ARNOLDUS, EPJ

WIEGANT, J

NOORDERMEER, IA

WESSELS, JW

BEVERSTOCK, GC

GROSVELD, GC

VANDERPLOEG, M

RAAP, AK

机构：

[1] ACAD HOSP LEIDEN,DEPT NEUROL,LEIDEN,NETHERLANDS

[2] LEIDEN STATE UNIV,DEPT HUMAN GENET,2333 AL LEIDEN,NETHERLANDS

[3] ERASMUS UNIV,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 54卷 / 3-4期

关键词：

D O I：

10.1159/000132972

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Double fluorescence in situ hybridization was used to detect Philadelphia (Ph) chromosomes in interphase nuclei and metaphases of patients with chronic myeloid leukemia. Application of cosmid probes for 3' ABL and 5' BCR sequences gave better results than libraries for chromosomes 9 and 22. The present approach may provide an alternative method for monitoring minimal residual disease in Ph+ CML patients.

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页码：108 / &

相关论文

共 18 条

[1] TRANSLOCATION OF C-ABL ONCOGENE CORRELATES WITH THE PRESENCE OF A PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].

BARTRAM, CR ;

DEKLEIN, A ;

HAGEMEIJER, A ;

VANAGTHOVEN, T ;

VANKESSEL, AG ;

BOOTSMA, D ;

GROSVELD, G ;

FERGUSONSMITH, MA ;

DAVIES, T ;

STONE, M ;

HEISTERKAMP, N ;

STEPHENSON, JR ;

GROFFEN, J .

NATURE, 1983, 306 (5940) :277-280

[2] DETECTION OF SINGLE-COPY GENES BY NONISOTOPIC INSITU HYBRIDIZATION ON HUMAN-CHROMOSOMES [J].

CHERIF, D ;

BERNARD, O ;

BERGER, R .

HUMAN GENETICS, 1989, 81 (04) :358-362

[3] RAPID METAPHASE AND INTERPHASE DETECTION OF RADIATION-INDUCED CHROMOSOME-ABERRATIONS IN HUMAN-LYMPHOCYTES BY CHROMOSOMAL SUPPRESSION INSITU HYBRIDIZATION [J].

CREMER, T ;

POPP, S ;

EMMERICH, P ;

LICHTER, P ;

CREMER, C .

CYTOMETRY, 1990, 11 (01) :110-118

[4] DETECTION OF CHROMOSOME-ABERRATIONS IN THE HUMAN INTERPHASE NUCLEUS BY VISUALIZATION OF SPECIFIC TARGET DNAS WITH RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION TECHNIQUES - DIAGNOSIS OF TRISOMY-18 WITH PROBE L1.84 [J].

CREMER, T ;

LANDEGENT, J ;

BRUCKNER, A ;

SCHOLL, HP ;

SCHARDIN, M ;

HAGER, HD ;

DEVILEE, P ;

PEARSON, P ;

VANDERPLOEG, M .

HUMAN GENETICS, 1986, 74 (04) :346-352

[5]

DELFAU MH, 1990, LEUKEMIA, V4, P1

[6]

DEVILEE P, 1988, CANCER RES, V48, P5825

[7]

HEISTERKAMP N, 1983, Journal of Molecular and Applied Genetics, V2, P57

[8]

HERMANS A, 1989, CANCER CEL, V7, P21

[9] INSITU HYBRIDIZATION AS A TOOL TO STUDY NUMERICAL CHROMOSOME-ABERRATIONS IN SOLID BLADDER-TUMORS [J].

HOPMAN, AHN ;

RAMAEKERS, FCS ;

RAAP, AK ;

BECK, JLM ;

DEVILEE, P ;

VANDERPLOEG, M ;

VOOIJS, GP .

HISTOCHEMISTRY, 1988, 89 (04) :307-316

[10] DIAGNOSIS OF CHRONIC MYELOID AND ACUTE LYMPHOCYTIC LEUKEMIAS BY DETECTION OF LEUKEMIA-SPECIFIC MESSENGER-RNA SEQUENCES AMPLIFIED INVITRO [J].

KAWASAKI, ES ;

CLARK, SS ;

COYNE, MY ;

SMITH, SD ;

CHAMPLIN, R ;

WITTE, ON ;

MCCORMICK, FP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5698-5702